| Kolo | Dátum | Domáci | Hostia | |||
|---|---|---|---|---|---|---|
| 1. | pi 23.7.2021 | AS Trenčín | FC ViOn Zlaté Moravce | 4:0 | (4:0) | |
| 4. | pi 13.8.2021 | AS Trenčín | MFK Ružomberok | 1:1 | (1:1) | |
| 6. | so 28.8.2021 | AS Trenčín | ŠKF Sereď | 0:0 | (0:0) | |
| 8. | so 18.9.2021 | AS Trenčín | FK Senica | 3:3 | (1:2) | |
| 10. | ne 3.10.2021 | AS Trenčín | FC Spartak Trnava | 0:1 | (0:0) | |
| 13. | ne 31.10.2021 | AS Trenčín | ŠK Slovan Bratislava | 2:3 | (1:0) | |
| 14. | pi 5.11.2021 | AS Trenčín | MFK Zemplín Michalovce | 4:2 | (2:0) | |
| 16. | so 27.11.2021 | AS Trenčín | DAC 1904 Dunajská Streda | 0:1 | (0:1) | |
| 18. | so 11.12.2021 | AS Trenčín | MŠK Žilina | 1:3 | (0:0) | |
| 20. | so 12.2.2022 | AS Trenčín | FK Pohronie | 3:0 | (1:0) | |
| 22. | so 26.2.2022 | AS Trenčín | MFK Tatran Liptovský Mikuláš | 2:2 | (1:1) | |
| nadstavba 2 | pi 11.3.2022 | AS Trenčín | FK Pohronie | 2:0 | (0:0) | |
| nadstavba 3 | so 19.3.2022 | AS Trenčín | FK Senica | 4:1 | (2:1) | |
| nadstavba 5 | ut 26.4.2022 | AS Trenčín | FC ViOn Zlaté Moravce | 4:3 | (2:1) | |
| nadstavba 8 | so 30.4.2022 | AS Trenčín | MFK Tatran Liptovský Mikuláš | 5:2 | (2:1) | |
| nadstavba 10 | so 21.5.2022 | AS Trenčín | MFK Zemplín Michalovce | 2:2 | (1:1) |


| # | Tím | Z | Skóre | B |
|---|---|---|---|---|
| 1. | Slovan |
18 | 38:26 | 39 |
| 2. | DAC 1904 |
18 | 34:13 | 38 |
| 3. | Spartak |
18 | 34:18 | 35 |
| 4. | Žilina |
18 | 42:25 | 34 |
| 5. | Zemplín |
18 | 28:30 | 25 |
| 6. | Podbrezová |
18 | 28:28 | 24 |
| 7. | Ružomberok |
18 | 20:26 | 20 |
| 8. | Tatran |
18 | 19:25 | 20 |
| 9. | Komárno |
18 | 20:29 | 19 |
| 10. | Trenčín |
18 | 14:31 | 18 |
| 11. | Košice |
18 | 24:38 | 14 |
| 12. | Skalica |
18 | 15:27 | 13 |